Sotalol hydrochloride is a non-selective beta-blocker beta 1 and beta-2 adrenergic receptors. It reduces heart rate and myocardial contractility, slows AV-conduction, reduces the absolute refractory period. Possesses strong antiarrhythmic effect, the mechanism of which is to increase the duration of action potential and extending the absolute refractory period in all areas of the cardiac conduction system (III class of anti-arrhythmic drugs). By blocking the beta 2-adrenergic receptors, increases andriol tc the tone of smooth muscles of the bronchi, vessels.
Indications for use:
Symptomatic cardiac arrhythmias (tachyarrhythmias) supraventricular origin, such as atrioventricular (nodal) paroxysmal tachycardia syndrome syndrome or paroxysmal atrial fibrillation the atria. Maintenance of normal sinus rhythm after knocking fibrillation or atrial flutter.
Severe symptomatic ventricular cardiac arrhythmias such as tachyarrhythmias and prevention with proven effectiveness.
Arrhythmia caused by excessive circulating catecholamines or increased sensitivity to catecholamines.
Chronic heart failure IIb – III stage, shock, hypotension, atrioventricular block 2 and 3 degrees, sinoatrial block, sick sinus syndrome, bradycardia, prolongation of the interval andriol tc, obliterating vascular disease, obstructive airway disease, metabolic acidosis, laryngeal edema, severe allergic rhinitis, hypersensitivity to the drug and sulfonamides, untreated pheochromocytoma.
Caution should be exercised when administering patients with recent myocardial infarction, diabetes, pheochromocytoma, psoriasis, as well as in patients with impaired renal function.
Treatment carried out under the control of parameters of heart rate, blood pressure. In the case of withdrawal of the drug dose should be reduced gradually.
Pregnancy and breast-feeding
Apply the medication during pregnancy and andriol tc breastfeeding should be only in the presence of life-saving indications.
Bradycardia, AV block, increased symptoms of heart failure, hypotension, bronchospasm.
There are – dizziness, headache, fatigue, drowsiness, paresthesias, cold extremities, muscle weakness. In rare cases – nausea, diarrhea, constipation, allergic skin reactions, insomnia, dry mouth, hypoglycemia, sexual dysfunction, depression. There are some reports of increased angina attacks, disturbances in visual acuity, corneal and conjunctival inflammation, syncope.
Interaction with other drugs
Care must be taken while using the drug with calcium antagonists such as diltiazem verpamil and, due to the combined chelate on the sinoatrial and atrioventricular nodes.
In applying in combination with other anti-arrhythmic drugs class I should avoid prescribing, lengthen andriol tc interval (especially quinidine type substances), which increases the risk of ventricular arrhythmias.
You should also avoid the simultaneous application of anti-arrhythmic drugs class III of, drugs: galoperdol, antihistamines astemizole and terfenadine, halofantrine (antimalarial peraparat) because of the risk of excessive interval prolongation.
The simultaneous use of a calcium antagonist and antihypertensive drugs, some tranquilizers, hypnotics drugs (tricyclic antidepressants, barbiturates, phenothiazines, and narcotic drugs), diuretics and vasodilators can cause a significant drop in blood pressure.
The negative chronotropic effect of the drug, and also caused them slowing of atrioventricular conduction may increase while the use of reserpine, clonidine, alfametildopa, guanfacine and cardiac glycosides.
Simultaneous use of insulin or oral antidiabetic drugs, particularly with increased physical activity, can cause a decrease in blood sugar or enhancing symptoms of hypoglycemia.
Dosing and Administration
Unless otherwise indicated, you can use the following scheme. initially recommended for the treatment of cardiac arrhythmias such as tachyarrhythmias take 40 mg 2 times a day. The usual daily dose is 160-320 mg. When the drug dose may need to be increased to 160 mg three times a day.
In ischemic heart disease and cardiac arrhythmias, as well as long-term use of the drug is recommended its gradual abolition. Cancel or change the dosing regimen of the drug to patients with life-threatening heart rhythm disturbances appoint a doctor. Patients andriol tc with a history of myocardial infarction or patients with impaired myocardial contractility, should be under the supervision of a cardiologist. Tablets are encouraged to take up the meal.