Treatment and control of the symptoms of benign prostatic hyperplasia.
Sonirid Duo can not be applied to women. Pregnant women and women of childbearing age should avoid contact with crushed or lose integrity finasteride tablets, andriol testocaps and should avoid contact with the men taking finasteride semen (use a condom).
Dosing and Administration
Duo Sonirid preparation contains 0.4 mg of tamsulosin capsules modified release and 5 mg finasteride tablets, film-coated. Preparations intended for daily admission. The daily dose of the drug Sonirid Duo comprises one capsule with a modified release tamsulosin and 0.4 mg per tablet, film-coated tablets, 5 mg of finasteride.
Tamsulosin 0.4 mg modified-release capsules, to be taken into one and the same time of day, after eating. Capsules should be swallowed whole, not chewed or crush, as this can disrupt the sustained release of the active compound.
For the full therapeutic effect requires long-term use of the drug Sonirid Duo. In case of adverse reactions can be transferred to the patient finasteride monotherapy; however it is recommended to return to the combined regimen with increased severity of BPH symptoms.
Adverse reactions tamsulosin monotherapy
Disorders of the nervous system:
Rare: syncope. Violations of the cardiovascular system: Infrequent: postural hypotension, tachycardia. Violations of the respiratory system, organs, thoracic and mediastinal disorders Uncommon: rhinitis;Violations on the part of the gastrointestinal tract: Uncommon: constipation, diarrhea, nausea, vomiting. Violations by the skin and subcutaneous fat: Infrequent: rash, pruritus, urticaria Rare: angioneurotic edema. reproductive system: Infrequent: retrograde ejaculation ; Rare: priapism.
Adverse reactions finasteride monotherapy
On the part of the immune andriol testocaps system
Infrequent:. Hypersensitivity part of the vision Infrequent:. Clouding of the lens of the gastrointestinal tract Common: abdominal pain. Skin and subcutaneous tissue Uncommon: rash. Reproductive system and mammary glands: Frequent : erectile dysfunction, ejaculation disorder, decreased volume of ejaculate, decreased libido; Infrequent: sore breasts, increased mammary glands, pain in the testicles. During post-marketing surveillance describes the following additional adverse reactions (data about the frequency of adverse reactions is not): – hypersensitivity reactions, including itching, hives, swelling of the lips and face.
Adverse reactions of the combined treatment
in patients receiving combination therapy (finasteride and alpha-1-blocker) described the same adverse reactions, occurring with the same frequency as monotherapy finasteride and alpha-1-adrenergic blocker. However, the following exceptions are identified: erectile dysfunction and ejaculation disorder detected more frequently in the combination therapy, whereas the progression of the disease (including the strengthening of BPH symptoms, or need for surgical treatment) were observed more frequently in monotherapy.
No cases of simultaneous overdose with finasteride and tamsulosin. There is no clinical data on overdose tamsulosin. Theoretically, an acute overdose tamsulosin may cause hypotension, which could lead to cardiovascular disorders. For recovery of blood pressure and heart rate of the patient must be laid if necessary to apply plasma-drugs and, depending on the condition of the patient, vasopressor medications. It is recommended to monitor renal function. Not shown dialysis due to tamsulosin significant binding to plasma proteins. In order to reduce absorption of the drug it is advisable to induce vomiting. Gastric lavage after taking large amounts of the drug should be carried out together with the appointment of activated charcoal and an osmotic laxative (eg, sodium sulfate). Overdose Finasteride:The use of a single dose andriol testocaps of finasteride 400mg and multiple reception at a dose of 80 mg / day for 3 months showed no adverse reactions. In case of overdose of specific treatment is required.