At simultaneous reception blockers “slow” calcium channel blockers such as verapamil and diltiazem may reduce the value as a result of the deterioration of contractility.
Avoid intravenous administration of these drugs during treatment with sotalol (except in cases of emergency medicine).
The combined use of antiarrhythmics class IA (especially quinidine type : disopyramide, quinidine, procainamide), or class III of (eg, amiodarone) can cause a pronounced prolongation of the interval laisa andriol.drugs that increase the duration of interval: should be used cautiously with drugs that prolong the interval , such as class I antiarrhythmics, phenothiazines , tricyclic antidepressants, terfenadine and astemizole, as well as some antibiotics quinolone series. At the same time taking nifedipine and other 1,4-dihydropyridine derivatives may reduce the magnitude of blood pressure. Concurrent administration of laisa andriol inhibitors or noradrenaline, and the abrupt withdrawal of clonidine may cause hypertension. In this case, the abolition of clonidine should be gradual, and only a few days after the deadline Sotageksala. Tricyclic antidepressants, barbiturates, phenothiazines, narcotics and antihypertensives, diuretics and vasodilators can cause a sharp decrease in blood pressure. The use of funds for inhalation anesthesia, in t. Ch. tubokurarina while taking Sotageksala increases the risk of depression of the myocardium and development of arterial hypotension. in an application Sotageksala withreserpine, clonidine, alpha-methyldopa, guanfacine and cardiac glycosides may develop severe bradycardia and slowing of conduction of excitation in the heart. Beta-blockers may potentiate hypertension cancellation after discontinuation of clonidine; therefore, beta-blockers should be withdrawn gradually, a few days before the gradual discontinuation of clonidine. Appointment of insulin or other oral hypoglycemic agents, especially during exercise, can lead to increased hypoglycemia and the manifestation of its symptoms (sweating, rapid pulse, tremor) . In diabetes requires correction dose of insulin and / or hypoglycemic agents. Kaliyvyvodyaschie diuretics (eg., Furosemide, hydrochlorothiazide) can provoke arrhythmia caused by hypokalemia. Stimulants beta2 receptor. In an application with Sotageksalom may require the use of higher doses of beta- agonists such as salbutamol, isoprenaline and terbutaline.
Cancel the drug
Hypersensitivity to catecholamines is observed in patients after the abolition of the beta-blockers.
Following abrupt cessation of therapy registered separate cases of exacerbation of angina, arrhythmia, and, in some cases, myocardial infarction. Therefore, we recommend careful monitoring of the patient, especially with coronary heart disease, if necessary, abrupt withdrawal of long-term therapy l. If possible, the dose should be reduced gradually over a period of one or two weeks. If necessary, it is recommended to initiate replacement therapy. Abrupt discontinuation of the drug can cause “hidden” coronary insufficiency, as well as the development of hypertension. Proarrhythmia The most dangerous side effect of antiarrhythmic drugs is a worsening of pre-existing arrhythmias or the provocation of new arrhythmias. Drugs that prolong the laisa andriol interval, may trigger tachycardia type “pirouette”, polymorphic ventricular tachycardia. The occurrence of these arrhythmias due to the lengthening of the interval laisa andriol, a decrease in heart rate, decrease of serum potassium and magnesium, high plasma concentrations of sotalol and simultaneous application other drugs prolonging the interval. In women, these complications occur more frequently. Tachycardia “pirouette” type usually occurs in the early stages after the start of therapy or when the dose is increased, and terminates spontaneously in the majority of patients. At this dose titration reduces the risk of proarrhythmia. Rarely tachycardia type “pirouette” can you progress to ventricular fibrillation. hoeveel kcal verbrand je met hardlopen